![]() ![]() 1 Gingivitis is mostly reversible, but long or repeated episodes of gingivitis, especially in susceptible individuals, can lead to the development of periodontitis-a chronic and destructive inflammatory disease in which host tissue is lost. The accumulation of dental plaque due to insufficient oral hygiene can facilitate the development of gingivitis. Our results suggest that an impaired NRC in periodontitis could limit dietary nitrate-derived nitric oxide levels, and the effect on systemic health should be explored in future studies. No significant effect of periodontal treatment on the baseline saliva and plasma nitrate and nitrite levels was found, indicating that differences in the NRC may only be revealed after nitrate intake. Additionally, the subgingival levels of nitrate-reducing bacteria increased after treatment and correlated negatively with periodontitis-associated bacteria ( P < 0.01). Salivary NRC was found to be diminished in periodontal patients before treatment ( P < 0.05) but recovered to healthy levels 90 days post-treatment. The oral NRC was determined in vitro by incubating saliva with 8 mmol/L nitrate (a concentration found in saliva after nitrate-rich vegetable intake) and compared with the NRC of 15 healthy individuals. Secondly, subgingival plaque, saliva, and plasma samples were obtained from 42 periodontitis patients before and after periodontal treatment. ![]() First, 16S rRNA sequencing data from five different countries were analyzed, revealing that nitrate-reducing bacteria were significantly lower in subgingival plaque of periodontitis patients compared with healthy individuals ( P < 0.05 in all five datasets with n = 20–82 samples per dataset). The current study aimed to evaluate how periodontitis affects the NRC of the oral microbiota. ![]() Studies of bacterial composition in subgingival plaque suggest that nitrate-reducing bacteria are associated with periodontal health, but the impact of periodontitis on nitrate-reducing capacity (NRC) and, therefore, nitric oxide availability has not been evaluated. The reduction of nitrate to nitrite by the oral microbiota has been proposed to be important for oral health and results in nitric oxide formation that can improve cardiometabolic conditions. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |